HPV

  • The mother of one of your adolescent patients asks you about human papillomavirus (HPV)vaccination. She explains that she has just learned that HPV is the most common sexually-transmitted infectious agent and that there are vaccines available to prevent infection. In discussing this virus, you inform her that there are more than 100 strains of the virus but that the vaccines protect against the most
    important strains.
  • Of the following, the MOST accurate specific information about HPV strains is that
    A. type 43 causes most recurrent respiratory papillomatosis
    B. types 11 and 35 account for most cervical cancer
    C. types 16 and 18 account for most cervical cancer
    D. types 6 and 54 account for most anogenital warts
    E. types 43 and 44 account for most anogenital warts
  • Of the more than 100 different types of the human papillomavirus (HPV), about 30 to 40 are
    responsible for anogenital infections and 15 to 20 of these are oncogenic (high risk). Persistent infection
    with these high-risk types is responsible for almost all cervical precancers and cancers as well as a high
    percentage of precancers and cancers at other anogenital sites in both sexes. Of the oncogenic strains,
    types 16 and 18 are responsible for two thirds of all cervical cancers worldwide.
  • Each year in the United States, approximately 12,000 women develop cervical cancer and nearly 4,000 die of it.
    Of the nononcogenic (low-risk) HPV types, types 6 and 11 together are responsible for greater than 90% of anogenital warts and almost 100% of recurrent respiratory papillomatosis, a rare nonmalignantlesion of the larynx and trachea that has a peak incidence between the ages of 2 and 4 years
  • The quadrivalent vaccine contains types 6, 11, 16, and 18. The bivalent vaccine contains types 16
    and 18. Types 43, 44, and 54 are low-risk types, and 33 and 35 are high-risk types, but they are not currently included in the vaccines because they account for few infections.

About Dr. Jayaprakash

Asst. Prof. of Pediatrics, ICH. Institute of Child Health. Gov. Medical College Kottayam. Kerala, India.

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